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目的:评价便携式加速度记录仪定量化监测帕金森病(PD)运动障碍的程度与症状波动。方法:51例PD患者根据Hoehn-Yahr分级分为轻症组(n=27)和重症组(n=24),将便携式加速度记录仪佩戴于患者手腕连续记录6d以上。评价PD患者的主观症状程度、解析localmaxima与localminima型身体活动的幂型自相关指数来监测患者的症状波动。对重症组和轻症组患者的状况好与差、抗PD药物使用前后进行比较。结果:所有PD患者,状况好或是治疗后患者的local maxima型幂型自相关指数值均小于症状重或治疗前,并且不受震颤的影响。结论:利用幂型自相关指数法解析加速度记录仪所记录的身体运动,能够客观定量化评价PD的程度,可作为PD患者门诊疗效评价的工具。
PURPOSE: To evaluate the extent and symptomatic fluctuations of portable acceleration recorders in the quantitative monitoring of Parkinson’s disease (PD) dyskinesia. Methods: Fifty-one PD patients were divided into mild group (n = 27) and severe group (n = 24) according to Hoehn-Yahr classification. The portable accelerograph was worn on the wrists for 6 days. To assess the subjective symptoms of PD patients and to analyze the power-dependent autocorrelation index of localmaxima and localminima-type physical activity to monitor the patient’s symptoms. The condition of patients in severe and mild group was good and bad, before and after anti-PD drug use were compared. RESULTS: In all PD patients, the local maxima exponential autocorrelation index of patients in good condition or after treatment was less than symptom weight or before treatment, and was not affected by tremor. Conclusion: The exponential autocorrelation exponent analysis of body motion recorded by accelerometer can objectively quantify the degree of PD, which can be used as a tool to evaluate the outpatient efficacy of PD patients.