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目的:分析基底细胞样型乳腺癌(BLBC)癌灶组织中拓扑异构酶α(TOPOIIα)的表达及意义。方法:88例BLBC导管浸润癌患者作为观察组,同期非基底细胞样型导管浸润癌患者76例作为对照组,采用免疫组织化学方法检测两组患者癌灶组织中TOPOIIα的表达,分析其与BLBC病理特征的关系。结果:观察组TOPOIIα表达阳性率明显高于对照组,差异有统计学意义(P<0.05);BLBC癌灶组织中TOPOIIα表达与淋巴结转移、临床分期有关,差异有统计学意义(P<0.05);与年龄、民族、肿瘤大小、肿瘤组织学分级及临床分期无关,差异无统计学意义(P>0.05)。结论:癌灶组织中TOPOIIα阳性表达与BLBC发生、发展有关。
Objective: To investigate the expression and significance of topoisomerase α (TOPOIIα) in basal cell carcinoma of breast cancer (BLBC). Methods: Eighty-eight patients with invasive ductal carcinoma of the BLBC were selected as observation group. 76 cases of invasive ductal carcinoma of non-basal cell type were selected as control group during the same period. The expression of TOPOIIα in the two groups were detected by immunohistochemical method. Pathological characteristics of the relationship. Results: The positive expression rate of TOPOIIα in observation group was significantly higher than that in control group (P <0.05). The expression of TOPOIIα in BLBC was correlated with lymph node metastasis and clinical stage (P <0.05) There was no significant difference between them (P> 0.05), but not with the age, ethnicity, tumor size, tumor histological grade and clinical stage. Conclusion: The positive expression of TOPOIIα in cancerous tissue is related to the occurrence and development of BLBC.