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目的观察奥美拉唑治疗胃食管反流病的临床效果。方法将胃食管反流病患者68例随机分为2组各34例,试验组给予奥美拉唑治疗,对照组给予雷尼替丁治疗,比较2组治疗前后各症状积分、胃镜分级情况及不良反应。结果治疗前2组各症状积分比较差异均无统计学意义(P>0.05);治疗12周后,2组胃烧灼感、反酸、咽部异物感积分明显降低,且试验组低于对照组,差异均有统计学意义(P<0.05)。治疗前2组胃镜分级比较差异无统计学意义(P>0.05);治疗后试验组胃镜检查0级所占比例为67.65%明显高于对照组的38.24%,Ⅲ级所占比例为0明显低于对照组的20.59%,差异均有统计学意义(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05),且均在停药后缓解。结论奥美拉唑治疗胃食管反流病可快速缓解患者临床症状,改善胃镜检查结果,且不良反应少,值得临床推广应用。
Objective To observe the clinical efficacy of omeprazole in the treatment of gastroesophageal reflux disease. Methods 68 cases of gastroesophageal reflux disease were randomly divided into two groups of 34 cases, the experimental group was treated with omeprazole, the control group was treated with ranitidine, two groups before and after treatment of symptom scores, gastroscopy grading and Adverse reactions. Results There was no significant difference in scores of symptom scores between the two groups before treatment (P> 0.05). After 12 weeks of treatment, the scores of burning sensation, acid reflux and foreign body sensation of pharynx in the two groups were significantly lower than those in the control group , The differences were statistically significant (P <0.05). There was no significant difference in gastroscope grading between the two groups before treatment (P> 0.05). After treatment, the gastroscopy grade 0 in the test group was 67.65%, significantly higher than that in the control group (38.24%), and the grade Ⅲ was 0 20.59% of the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05), and were relieved after stopping treatment. Conclusion Omeprazole treatment of gastroesophageal reflux disease can quickly alleviate the clinical symptoms of patients, to improve the results of gastroscopy, and fewer adverse reactions, it is worthy of clinical application.