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四逆散是一个著名的中药复方,长久以来用于治疗抑郁症。在本研究中,我们探索了四逆散提取物对于社会竞争失败树鼩抑郁模型的作用及可能机制。动物分为4组,除了空白组外,其他动物接受5周的社会竞争失败应激,后4周分别给予四逆散提取物(3.6 g/kg/d),氟西汀(15 mg/kg/d)与蒸馏水。结果表明,四逆散提取物可以逆转慢性应激造成的体重下降和尿/血皮质醇升高;还可以升高海马中去甲肾上腺素的水平。结果证明,四逆散提取物对于社会竞争失败树鼩抑郁模型的主要症状有治疗作用,机制可能与缓解应激后高度活跃的下丘脑—皮质—肾上腺轴有关。
Sini Powder is a famous traditional Chinese medicine compound that has long been used to treat depression. In this study, we explored the role and possible mechanisms of Sini-San extract for a tree model of depression in social competition. The animals were divided into 4 groups. Except for the blank group, other animals underwent 5 weeks of unsuccessful social competition. After 4 weeks, the animals were given Sini Decoction (3.6 g / kg / d), fluoxetine (15 mg / kg / d) with distilled water. The results showed that Sini extract can reverse chronic stress caused by weight loss and urinary / cortisol increased; also increase the level of norepinephrine in the hippocampus. The results show that Sini-San extract has a therapeutic effect on the main symptoms of tree depression depression model of social failure, and the mechanism may be related to the relief of the highly active hypothalamus-cortex-adrenal axis after stress.