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目的观察健骨方对大鼠骨关节炎软骨细胞中p38丝裂原活化蛋白激酶(p38 MAPK)表达的影响。方法选用SD大鼠40只,采用Hulth法制备大鼠膝骨关节炎模型,以健骨方灌胃为干预治疗手段,Western blotting测定各组p38 MAPK表达水平。结果Western blotting显示p38 MAPK在对照组持续表达,而健骨方组的表达明显下降(P<0.05)。结论健骨方可有效影响p38 MAPK的表达。
Objective To observe the effects of “Jiangu Fang” on the expression of p38 mitogen activated protein kinase (p38 MAPK) in osteoarthritis chondrocytes of rats. Methods Forty SD rats were used to establish the model of knee osteoarthritis in rats by Hulth method. The intervention of Jiangu recipe was taken as intervention, and the expression of p38 MAPK in each group was determined by Western blotting. Results Western blotting showed that p38 MAPK was consistently expressed in the control group, while the expression in the Jiangufang group was significantly decreased (P <0.05). Conclusion Jiangufang can effectively affect the expression of p38 MAPK.