作者利用支气管肺泡灌洗技术对大鼠矽尘性肺泡炎进行了细胞学、酶组化及生化的研究。发现以中性粒细胞及肺泡巨噬细胞为主的炎细胞持续浸润,肺泡巨噬细胞和中性粒细胞的损伤和崩解,及肺泡结构的急性损伤是矽尘性肺泡炎的主要特点。作者并结合文献讨论了矽尘在肺组织内对肺泡巨噬细胞的作用,以及矽尘性肺泡炎在矽肺纤维化发生中的意义。 The authors used the bronchoalveolar lavage technique to investigate the cytological, enzymatic histochemical and biochemical studies of silica dust alveolitis in rats. Found that neutrophils and alveolar macrophages-based inflammatory cells continue to infiltrate, alveolar macrophages and neutrophils damage and disintegration, and the alveolar structure of the acute injury is the main features of silicosis pneumonic alveolitis. The author and the literature discussed the role of silica dust in alveolar macrophages in the lung tissue, as well as silicotic alveolar inflammation in the occurrence of silicosis.