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目的：研究细胞间粘附因子１（ＩＣＡＭ１）在着床期外周血淋巴细胞（ＰＢＬＣ）、子宫内膜及蜕膜细胞（ＥＣ／ＤＣ）中的不同表达特点及动态变化规律。方法：以着床期小鼠为动物模型，细胞分析采用单抗免疫荧光标记及多参数流式细胞术分析技术。结果：发现ＩＣＡＭ１在ＰＢＬＣ、ＥＣ／ＤＣ中的表达均存在明显的动态变化；其中ＩＣＡＭ１的表达在ＰＢＬＣ中于妊娠第２天（Ｄ２）达最低水平，而在ＥＣ／ＤＣ中于妊娠第４天（Ｄ４）降至最低。结论：ＩＣＡＭ１在ＰＢＬＣ及ＥＣ／ＤＣ中的动态表达具有不同的调控机制，这种动态变化参与了着床过程中局部免疫耐受的形成及调控。
Objective: To study the different expression characteristics and dynamic changes of ICAM1 in peripheral blood lymphocytes (PBLC), endometrium and decidual cells (EC / DC) during implantation. METHODS: The implantation mice were used as animal models. The cells were analyzed by monoclonal antibody immunofluorescence and multi-parameter flow cytometry. Results: The expression of ICAM-1 in PBLC and EC / DC showed significant dynamic changes. Among them, the expression of ICAM-1 reached the lowest level in PBLC on day 2 of pregnancy (D2), while in EC / DC Day 4 of gestation (D4) is minimized. CONCLUSION: The dynamic expression of ICAM-1 in PBLC and EC / DC has different regulatory mechanisms. This dynamic change is involved in the formation and regulation of local immune tolerance during implantation.