用电生理细胞内微电极和膜片钳单通道记录技术,研究了21种磷酰胺酯化学结构对昆虫谷氨酸电位和谷氨酸受体单通道开关动力学门控过程的作用。结果表明:(1)21种化合物均能阻断谷氨酸电位,其中BSSN-01表现明显的兴奋过程;(2)BSSN-01可调制谷氨酸单通道的门控过程,通道道通时间延长,约τ_2=2.75ms,比正常值τ_1=2.1ms增加约31％,从而改变了通道的时间依赖性。 The electrophysiological intracellular microelectrode and patch-clamp single-channel recording technique was used to study the effects of 21 phosphoramidite chemical structures on insect glutamate potentials and glutamate receptor single-channel switch gating processes. The results showed that: (1) all the 21 compounds could block glutamate potentials, of which BSSN-01 showed obvious excitatory processes; (2) BSSN-01 could modulate the glutamatergic single- , About τ_2 = 2.75ms, which is about 31% more than the normal value of τ_1 = 2.1ms, thus changing the channel’s time dependence.