论文部分内容阅读
已证明心肌细胞有血管紧张素Ⅱ结合位点,血管紧张素及其类似物对心肌具有正性变力作用,因而设想心肌可能存在局部性肾素血管紧张素系统。实验证明,雄性 CD-1小鼠及 SD 大鼠(sprague dawley rats)心脏有肾素样活性物质。这种心脏肾素和肾脏肾素具有类似的最适 pH,可被抗肾素抗体抑制。由于在体外分离出的雄性 Wistar-Kyoto 大鼠心室细胞仍可测到肾素样活性物质,以及低钠饮食小鼠心肌细胞和大鼠心脏中均存在肾素的 mRNA,因而认为肾素是在心肌局部合成的,不是来源于血液;同时还观察到硝苯吡啶可降低心室细胞肾素活性。心脏局部的肾素—血管紧张素系统的意义如下:(1)血管紧张素Ⅱ对心肌有正
It has been demonstrated that myocardial cells have a binding site for angiotensin II, and that angiotensin and its analogues have a positive variable effect on the myocardium, thus envisaging a possible localized renin-angiotensin system in the myocardium. Experiments show that male CD-1 mice and sprague dawley rats have renin-like active substance in the heart. This heart renin and kidney renin have similar optimal pH and are inhibited by anti-renin antibodies. Since renin-like actives were still detected in ventricular cells from male Wistar-Kyoto rats isolated in vitro, and renin mRNA was present in both low-sodium dietary cardiomyocytes and rat hearts, renin was considered Myocardial synthesis, not derived from the blood; also observed that nifedipine can reduce ventricular cell renin activity. The significance of the local renin-angiotensin system in the heart is as follows: (1) Angiotensin II is positive for the myocardium