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目的 评价介入性热化疗对兔肝癌的抑瘤效果。方法 将VX2瘤细胞接种于 6 0只新西兰白兔肝左叶 ,建立免肝癌模型 ,随机分 4组 ,每组 15只。利用导管经肝动脉分别给生理盐水、超液态碘化油、ADM溶液 ( 37℃ )、ADM溶液 ( 6 0℃ )于不同组 ,1周后观察各组肿瘤体积及血清AST水平 ,观察瘤兔的存活期。结果 ADM溶液 ( 6 0℃ )热灌注组生长率 ( 0 .5 3± 0 .2 1)与对照组 ( 3.48± 1.17)相比有显著性差异 (Ρ <0 .0 1) ,与栓塞组 ( 1.13± 0 .2 3)、ADM溶液 ( 37℃ )灌注组 ( 1.0 9± 0 .2 6 )相比亦有显著性差异 (Ρ<0 .0 5 )。ADM溶液 ( 6 0℃ )热灌注组存活期 ( 5 0 .0± 3.0d)与对照组 ( 4 0 .5± 3.0d)相比差异有显著性 (Ρ <0 .0 5 )。ADM溶液( 6 0℃ )热灌注组血清AST水平治疗前后变化与其它各组相比无显著性差异 (Ρ >0 .0 5 ) ,与对照组相比差异有显著性 (Ρ <0 .0 5 )。结论 ADM溶液 ( 6 0℃ )热灌注组可大大降低肿瘤生长率 ,延长存活期 ,对肝功的损害是可逆的 ,其抑瘤效果更强。
Objective To evaluate the anti-tumor effect of interventional thermochemotherapy on rabbit liver cancer. Methods VX2 tumor cells were inoculated on the left lobe of 60 rabbits in New Zealand white rabbits to establish a model of liver cancer free. Four groups were randomly divided into 15 groups. Tumor volume and serum AST levels in each group were observed with saline, supercritical iodized oil, ADM solution (37 ℃) and ADM solution (60 ℃) in different groups, respectively. Survival. Results Compared with the control group (3.48 ± 1.17), there was a significant difference (P <0.01) in the rate of growth in the ADM group (60 ℃) compared with the control group (P0.51 ± 0.21) (1.13 ± 0.23), ADM solution (37 ℃) perfusion group (1.09 ± 0.226), there was also a significant difference (P <0.05). There was a significant difference (P <0.05) between the ADM group (60 ℃) and the control group (4.0 ± 3.0d). There was no significant difference in the level of serum AST before and after treatment with ADM solution (60 ℃) compared with other groups (P> 0.05), and the difference was significant compared with the control group (P <0. 0 5). CONCLUSION: Thermal perfusion with ADM solution (60 ℃) can significantly reduce the tumor growth rate and extend the survival period. The damage to liver function is reversible and its anti-tumor effect is stronger.