【摘 要】
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Dear Editor,rnItch (pruritus) is an unpleasant somatic sensation that is accompanied by the desire to scratch.While itch provides a warning signal that protects us from potential threats in normal conditions,severe or chronic itch associated with dermatos
【机 构】
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Department of Human Anatomy,School of Medicine,Nantong University,Nantong 226001,China;Institute of
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Dear Editor,rnItch (pruritus) is an unpleasant somatic sensation that is accompanied by the desire to scratch.While itch provides a warning signal that protects us from potential threats in normal conditions,severe or chronic itch associated with dermatosis or systemic diseases is often difficult to alleviate and causes severe skin and tissue damage.In recent years,considerable advances have been made in the molecular and cellular mechanisms underlying itch at the peripheral and spinal levels.For example,Mas-related G-protein-coupled receptor A3+ neurons in the dorsal root ganglion (DRG) specifically carry information about itch[1].In addition,natriuretic polypeptide b (NPPB),which has been identified as an itch-selective neuropeptide,can be released from the primary afferents and act on the NPPBreceptor NPRA in the spinal dorsal horn [2].
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