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目的通过对６４例老年急性脑血管意外患者发病初期及病后２周血清超氧化物歧化酶（ＳＯＤ）活性及丙二醛（ＭＤＡ）含量的研究，可进一步了解脑血管疾病与氧自由基的关系。方法分析我院１９９５年至１９９６年４月收治的急性脑血管意外患者６４例（脑出血、脑梗塞各３２例），在其发病的初期（３天内）与病后２周分别抽血检查了ＳＯＤ及ＭＤＡ含量。并选择了６０例健康老人作对照组。结果脑出血、脑梗塞组患者发病初期ＳＯＤ活性明显低于对照组，而ＭＤＡ含量明显增高，以脑出血组更为显著，２组比较Ｐ＜０．００１。２周后２组病人的两项指标均有恢复，但Ｐ值仍有显著差异，仅少数脑梗塞病人恢复至正常范围内。结论本研究证实急性脑血管意外患者在急性期血氧自由基产生增加，且病情危重程度与ＭＤＡ呈正相关。因此，临床上可根据上述两项值作为估计病情、判断预后及评价疗效的一项参考指标。也为临床抗氧化治疗提供了参考依据。
Objective To further understand the relationship between cerebrovascular diseases and oxygen free radicals by analyzing the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in 64 elderly patients with acute cerebrovascular accident at the onset and 2 weeks after illness relationship. Methods 64 cases of acute cerebrovascular accident (32 cases of cerebral hemorrhage and cerebral infarction) admitted to our hospital from 1995 to April 1996 were analyzed respectively. Blood samples were collected during the initial period (within 3 days) and 2 weeks after the disease SOD and MDA content. 60 healthy elderly people were selected as the control group. Results The activity of SOD in the early stage of cerebral hemorrhage and cerebral infarction patients was significantly lower than that in the control group, while the content of MDA was significantly increased in the cerebral hemorrhage group. The two groups were significantly less than those in the two groups Indicators were restored, but the P value is still significant differences, only a few patients with cerebral infarction returned to normal range. Conclusions This study demonstrates that patients with acute cerebrovascular accident have an increased production of free radical oxygen free radicals in the acute phase and the severity of the disease is positively correlated with MDA. Therefore, clinically based on the above two values as the estimated disease, prognosis and evaluation of the efficacy of a reference index. It also provides a reference for clinical anti-oxidative therapy.