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目的:探讨绝经后女性内源性性激素及血脂水平与乳腺癌的关系以及作为预测指标的可行性。方法:收集2011年7月—2014年6月期间手术治疗的绝经后女性乳腺癌患者274例(乳腺癌组)与同期因其他疾病收治的非乳腺疾病的绝经后患者279例(对照组);比较两组间性激素与血脂水平的差异,分析可能的乳腺癌预测指标。结果:乳腺癌组的雌二醇(E2)与睾酮(T)水平明显高于对照组(均P<0.05),其他性激素与血脂指标两组间差异均无统计学意义(均P>0.05)。分层分析显示,随E2与T水平升高,乳腺癌发病率增加,其中E2水平对乳腺癌的预测有较好的敏感性和特异性,受试者操作特征(ROC)曲线下面积(AUC)为0.730(95%CI=0.649~0.811),但T水平的预测作用不明显。结论:E2与T水平与绝经后女性乳腺癌有关,其中E2水平可作为预测因子之一,但尚未达到良好或者优秀标准。
Objective: To investigate the relationship between endogenous sex hormones and blood lipids and breast cancer in postmenopausal women and the feasibility of using it as a predictor. METHODS: A total of 274 postmenopausal women with breast cancer (breast cancer group) and 279 postmenopausal women with non-breast disease (control group) were enrolled in this study. Differences in the levels of sex hormones and blood lipids were compared between the two groups and the possible predictors of breast cancer were analyzed. Results: The levels of estradiol (E2) and testosterone (T) in breast cancer group were significantly higher than those in control group (all P <0.05). There was no significant difference between the other sex hormones and serum lipids (P> 0.05) . Hierarchical analysis showed that as the level of E2 and T increased, the incidence of breast cancer increased, in which the E2 level had a good sensitivity and specificity for breast cancer prediction. The area under the receiver operating characteristic (ROC) curve (AUC ) Was 0.730 (95% CI = 0.649 ~ 0.811), but the predictive value of T level was not obvious. Conclusion: The levels of E2 and T are related to breast cancer in postmenopausal women. The level of E2 may be one of the predictors, but the good or excellent standard has not been reached yet.