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用Pyrogallol-NBT等方法测定并分析荷瘤伴感染组及荷瘤非感染组小鼠肿瘤内超氧化物歧化酶(SOD)和丙二醛(MDA)含量对小鼠生存天数的影响。结果发现荷瘤伴感染组小鼠的平均存活天数明显短于荷瘤非感染组及正常对照组,P<0.01。荷瘤伴细菌感染组小鼠肿瘤内MDA含量明显高于荷瘤非感染组及L型感染组,P<0.05~0.01。98.7%荷瘤小鼠肿瘤内SOD含量极低或为零。另有5只小鼠经3次接种肿瘤,均未见肿瘤生长,其肝脏内SOD含量高于正常对照组,P<0.02。提示感染可使小鼠肿瘤内MDA量增高,SOD量减少,可能是荷瘤伴感染组小鼠生存天数短于荷瘤非感染组及正常对照组的重要原因之一。
Pyrogallol-NBT and other methods were used to measure and analyze the effect of the content of superoxide dismutase (SOD) and malondialdehyde (MDA) in mice with tumor-bearing with infection and tumor-bearing non-infected mice on the survival days of mice. The results showed that the average survival time of mice with tumor-bearing infection group was significantly shorter than that of non-tumor-bearing group and normal control group (P <0.01). The tumor MDA content in tumor-bearing mice with bacterial infection was significantly higher than that in non-tumor-bearing and L-type infected mice, P <0.05 ~ 0.01. 98.7% tumor-bearing mice with very low level of SOD Or zero. In addition, 5 mice were inoculated with tumor three times without any tumor growth. The content of SOD in the liver was higher than that in the normal control group (P <0.02). Tip infection can increase the amount of MDA in tumor mice, SOD decreased, may be tumor-bearing with infection in mice survival days shorter than non-tumor-bearing non-infected group and normal control one of the important reasons.