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目的:探讨脐血NSE、TNF-α与VEGF水平对脑瘫高危儿的早期预测价值。方法:研究对象分为3组:早产儿+高危因素组(1组)、足月儿+高危因素组(2组)与正常足月儿组(3组)。应用酶联免疫吸附法检测脐血NSE、TNF-α与VEGF水平。3个组均随访至3岁(死亡及诊断为脑瘫者终止)。结果:与3组相比较,1组与2组NSE、TNF-α与VEGF水平明显增高(P<0.05)。至随访结束发现脑性瘫痪患儿9例(10.0%),其中1组为7例(25.9%),2组为2例,3组未发现脑瘫患儿。脑瘫组与非脑瘫组相比较,脑瘫组NSE、TNF-α与VEGF水平明显增高(P<0.05)。结论:脐血NSE、TNF-α与VEGF水平测定可以辅助早期预测脑瘫高危儿。
Objective: To investigate the predictive value of NSE, TNF-α and VEGF levels in cord blood of high risk infants with cerebral palsy. Methods: The subjects were divided into three groups: premature infant + high risk group (group 1), term infants + high risk group (group 2) and normal term group (group 3). Serum levels of NSE, TNF-α and VEGF were detected by enzyme-linked immunosorbent assay. All three groups were followed up to 3 years old (died and diagnosed as cerebral palsy termination). Results: Compared with the 3 groups, the levels of NSE, TNF-α and VEGF in group 1 and group 2 were significantly increased (P <0.05). At the end of follow-up, 9 cases (10.0%) of children with cerebral palsy were found, including 7 cases (25.9%) in group 1, 2 cases in group 2, and no children with cerebral palsy in 3 groups. The levels of NSE, TNF-α and VEGF in cerebral palsy group were significantly higher than those in non-cerebral palsy group (P <0.05). Conclusion: The determination of NSE, TNF-α and VEGF levels in umbilical cord blood can be used to predict the high risk infants with cerebral palsy in the early stage.