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本文通过芳氧基负离子在2—甲磺酰基—苯基—1,3,4—噁二唑环2—位上的亲核取代反应制得9个新的2—芳氧基—5—苯基—l,3,4—噁二唑衍生物。所有化合物的结构经元素分析,IR,~1H NMR和MS确认。初步抗菌实验表明这些化合物具有一定的抑制枯草芽孢杆菌繁殖的活性。 2,5—二取代l,3,4—噁二唑衍生物具有广泛的生物活性,如抗菌,抗黄球菌,除草杀棉花牙虫等。Madhavan等曾通过芳胺在2— 甲磺酰基—5—芳基1,3,4—噁二唑环上的亲核取代反应,制得了2—芳氨基—5—芳基—l,3,4—噁二唑衍生物,我们也曾通过酰肼等亲核试剂在2—甲磺酰基—5—(3,4,5—三甲氧基苯基)—1,3,4—噁二唑环上的亲核取代反应,得到了2—取代酰肼基—5—(3,4,5—三甲氧基苯基)—l,3,4—噁二唑衍生物。在此基础上,我们拟通过Aro在2—甲磺酰基
In this paper, nine new 2-aryloxy-5-benzene derivatives were obtained by nucleophilic substitution of the aryloxy anion on the 2-position of 2-methanesulfonyl-phenyl-1,3,4-oxadiazole ring Yl-3,4-oxadiazole derivatives. The structures of all compounds were confirmed by elemental analysis, IR, ~ 1H NMR and MS. Preliminary antibacterial experiments show that these compounds have a certain inhibition of Bacillus subtilis breeding activity. 2,5-disubstituted l, 3,4-oxadiazole derivatives with a wide range of biological activity, such as antibacterial, anti-yellowing bacteria, weed killing cotton teeth and other insects. Madhavan et al. Have prepared 2-arylamino-5-aryl-1,3-oxadiazoles by nucleophilic substitution of aromatic amines on 2-methanesulfonyl-5-aryl 1,3,4-oxadiazole rings 4-oxadiazole derivatives, we have also used nucleophiles such as hydrazide in the 2-methanesulfonyl-5- (3,4,5-trimethoxyphenyl) -1,3,4-oxadiazole The nucleophilic substitution reaction on the ring gave the 2-substituted hydrazino-5- (3,4,5-trimethoxyphenyl) -l, 3,4-oxadiazole derivative. On this basis, we intend to pass Aro at 2-methanesulfonyl