forskolin(F)是一种植物二萜,又是人们熟知的腺苷酸环化酶(AC)激活剂。与霍乱毒素和氟不同,它直接作用于AC催化亚单位。它还可通过G蛋白影晌受体介导的过程,协助激素对AC活性的调节。根据采用百日咳毒素进行的研究,作者以往的工作表明,低剂量的forskolin对AC和cAMP生成具有一种新奇的,高亲和力的抑制作用。在此,作者又报道了forskolin的另一种抑制作用。 Forskolin (F) is a plant diterpene and is also known as adenylate cyclase (AC) activator. Unlike cholera toxin and fluorine, it acts directly on the AC catalytic subunit. It can also influence receptor-mediated processes through G proteins to assist hormonal regulation of AC activity. Based on studies using pertussis toxin, previous work by the authors showed that low doses of forskolin have a novel, high-affinity inhibitory effect on AC and cAMP production. Here, the authors report another inhibitory effect of forskolin.