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目的：探讨抗退饮解热机制。方法：建立家兔ＬＰ 发热模型，观察抗退饮灌胃对家兔体温的影响和用放射免疫分析法检测腹 中隔ＡＶＰ 含量及下丘脑ｃＡＭＰ 含量的变化。结果：（１） 抗退饮灌胃＋ 静注ＬＰ 组的△Ｔ 为（０－５１ ±０－２５） ℃、中隔区ＡＶＰ 含量为（１１－９５ ±４－５２） ｐｇｍｇ 、下丘脑ｃＡＭＰ 含量为（０－９１３ ±０－４５０） ｐｍｏｌｍｇ 、分别低于ＮＳ 灌胃＋ 静注ＬＰ 组的△Ｔ（１－１８ ±０－２７） ℃、中隔区ＡＶＰ 含量（２２－３７ ±３－５８） ｐｇｍｇ 、下丘脑ｃＡＭＰ 含量（１－５６２ ±０－３６０） ｐｍｏｌｍｇ（ Ｐ＜０－０１） 。（２） 中隔区ＡＶＰ 含量变化与体温变化呈明显正相关（ｒ ＝ ０－７８２ ，Ｐ＜ ０－０１） 。结论：抗退饮解热机制可能是通过抑制下丘脑ｃＡＭＰ 含量升高，同时促进腹中隔ＡＶＰ 释放两种途径发挥作用
Objective: To explore antipyretic antipyretic mechanism. METHODS: A rabbit model of febrile fever was established. The effects of anti-emetic drinking on rabbits’ body temperature and the changes of AVP content and cAMP content in the hypothalamus were detected by radioimmunoassay. RESULTS: (1) The △T for anti-eating and intragastric administration plus intravenous injection in the LP group was (0-51 ±0-25) °C, and the AVP content in the septal area was (11-95 ±4-52) pgmg. The content of cAMP in the thalamus was (0-913±0-450) pmolmg, which was lower than that of NS in the NS-injected and intravenously-injected LP group (1-18±0-27) °C, and the content of AVP in the septal area (22- 37 ±3-58) pgmg, hypothalamic cAMP content (1-562 ±0-360) pmolmg (P<0-01). (2) There was a significant positive correlation between changes in AVP content in the septal area and body temperature (r = 0-782, P < 0-01). Conclusion: The mechanism of antipyretic antipyretic activity may be through inhibiting the increase of cAMP content in the hypothalamus and promoting the release of AVP in the ventral septum.