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抑制伯氏疟原虫感染RBC中50％精脒量,抗氯喹株需要喂服400mg/kg氯喹,而敏感的为20mg/kg,相差至少20倍。两株感染鼠同样喂服氟喹20mg/kg和400mg/kg一次,3小时后,在全血和感染RBC中的氯喹量,低剂量组接近,400mg/kg组抗氯喹的更高,而积聚在疟原虫中的氯喹量则抗氯喹的低于敏感。抗氯喹感染RBC中的精脒,78‰集中在疟原虫,故认为精脒量的提高,可能与氯喹进入疟原虫产生竞争性抑制。MGBG抑制抗氯喹鼠中的疟原虫生长,精脒能逆转其作用。
Inhibition of Plasmodium berghei infection RBC in 50% of the amount of spermine, chloroquine resistant strains need to feed 400mg / kg chloroquine, and sensitive to 20mg / kg, a difference of at least 20 times. The two infected mice were also fed fluoroquinol 20 mg / kg and 400 mg / kg once. After 3 hours, the doses of chloroquine in whole blood and infected RBC were close to those in the low dose group, while those in the 400 mg / kg group were higher than that of chloroquine The amount of chloroquine in Plasmodium is less sensitive than chloroquine. Resistant to chloroquine infected RBC spermidine, 78 ‰ concentrated in the malaria parasite, so that the amount of spermine, may be competitive with chloroquine into the parasite to produce inhibition. MGBG inhibited Plasmodium growth in chloroquine-resistant mice and spermidine reversed its effects.