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14例正常男性志愿者应用复方十一酸睾酮,即十一酸睾酮(TU)+甲孕酮(MPA)。方法是每月肌肉注射一次,每次TU250mg+MPA200mg,持续4个月。所有病例至少随访12个月,精子生成都受到严重抑制,精子数在开始治疗后的1～4个月内下降到4百万/毫升以下,并继续下降直到零(即无精子)。停药后2～7个月内生精功能完全恢复,9例甚至超过用药前的1～16.9倍。3例试验者的配偶后来怀孕。副作用主要是:体重增加、平均5.2kg,血清睾酮水平下降和催乳素水平升高。3例于停药后10个月发现男乳发育。
Forty normal male volunteers applied testosterone undecanoate, ie, testosterone undecanoate (TU) + MPA. The method is intramuscular injection once a month, each TU250mg + MPA200mg, for 4 months. All cases were followed up for at least 12 months and spermatogenesis was severely inhibited. The number of sperm decreased to below 4 million / milliliter within 1 to 4 months after starting treatment and continued to decline until zero (ie, no sperm). 2 to 7 months after stopping the function of spermatogenesis completely restored, 9 cases even more than before treatment of 1 to 16.9 times. The spouse of 3 trial participants later became pregnant. Side effects are mainly: weight gain, an average of 5.2kg, serum testosterone levels decreased and elevated prolactin levels. Three cases of male milk development were found 10 months after discontinuation.