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目的研究溃疡性结肠炎（ＵＣ）患者部分粘附分子的变化意义．方法用流式细胞术测定３４例ＵＣ患者（男１４例，女２０例，平均年龄３１４岁）组织及血液中粘附分子ＣＤ４４、可溶性粘附分子Ｐ选择素（ＣＤ６２ｐ）、可溶性细胞间粘附分子－１（ＩＣＡＭ１，ＣＤ５４）的变化，并与２０例正常人（男８例，女１２例，平均年龄３０６岁）比较．结果ＵＣ患者组织和血液中ＣＤ４４（２０３％±８３％，１９４％±６３％），ＣＤ６２ｐ（５３％±２６％）、ＣＤ５４（１８３％±５９％）较正常人（９７％±４６％，７８％±４５％，１９％±０９１％，６２％±３７％）明显升高（Ｐ＜００１），缓解期ＵＣ患者上述指标（１５２％±７８％，１４４％±６８％，３８％±２４％，１３７％±５４％）较活动期（２６１％±１０２％，２３８％±７９％，６９％±３７％，２４１％±６７％）显著下降（Ｐ＜００５），但仍明显高于正常人（Ｐ＜００５）．组织中ＣＤ４４含量与外周血中接近（Ｐ＞００５），但伴有重度不典型增生者明显升高（３４７％±４６％ｖｓ２６１％±４２％，Ｐ＜００５）．结论粘附分子水平增加在Ｕ?
Objective To study the changes of some adhesion molecules in patients with ulcerative colitis (UC). Methods Flow cytometry was used to detect the expression of adhesion molecule CD44, soluble adhesion molecule P-selectin (CD62p) and soluble cells in 34 UC patients (14 males and 20 females with an average age of 314 years) Adhesion molecule-1 (ICAM 1, CD54) changes, and with 20 normal subjects (8 males and 12 females, mean age 30.6 years) compared. Results CD44 (203 ± 83%, 194% ± 63%), CD62p (53 ± 26%), CD54 (183% ± 59%) than normal people (97% ± 46%, 78% ± 45%, 19% ± 091%, 62% ± 37%) (P <001). The above indexes of remission UC patients (152% ± 78%, 144% ± 68%, 38% ± 24%, 137 % ± 54%) compared with active stage (261% ± 102%, 238% ± 79%, 69% ± 37%, 241% ± 67% ) Was significantly decreased (P <005), but still significantly higher than normal (P <005). The level of CD44 in the tissue was similar to that in the peripheral blood (P> 0.05), but those with severe atypical hyperplasia were significantly increased (34.7% ± 4.6% vs 26.4% ± 4.2%, P < 0 05). Conclusion Adhesion molecules increased in U?