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目的:研究新疆维吾尔族妇女的HPV感染与宫颈癌发病的关系,为HPV疫苗引进提供理论依据。方法:选择新疆维吾尔族妇女CIN2/3和宫颈癌共100例,进行高危型HPV亚型检测。结果:新疆维吾尔族妇女CIN2以上病变中,主要为单一HPV16感染,其次为多重感染。在多重HPV亚型感染中,主要为HPV16、18感染、HPV16、58感染、HPV16、18、58感染(5.88%)。CIN2/3与宫颈癌中的多重HPV亚型感染率无差异(x2=0.638,P=0.424))结论:新疆维吾尔族妇女HPV16感染在宫颈癌的发生中起着重要作用,且主要以HPV16单一感染为主。多重HPV感染在宫颈癌的发生中不起主要作用。
Objective: To study the relationship between HPV infection and cervical cancer in Uygur women in Xinjiang, and provide a theoretical basis for the introduction of HPV vaccine. Methods: A total of 100 Uighur women with cervical cancer were enrolled in this study. High-risk HPV subtypes were detected. Results: Uyghur women in Xinjiang Uighur CIN2 lesions were mainly single HPV16 infection, followed by multiple infections. Among the multiple HPV subtypes, HPV16,18 infection, HPV16,58 infection and HPV16,18,58 infection (5.88%) were the major causes. CIN2 / 3 and cervical cancer in multiple HPV subtype infection rate was no difference (x2 = 0.638, P = 0.424)) Conclusion: Uygur women in Xinjiang Uighur HPV16 infection plays an important role in the occurrence of cervical cancer, and mainly HPV16 single Infection-based. Multiple HPV infections can not play a major role in the development of cervical cancer.