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目的 研究肿瘤坏死因子、白介素 - 1β在脑缺血 /再灌注损伤中的作用及雷公藤多糖甙对其影响。方法 用线栓法建立大鼠脑缺血 /再灌注动物模型 ,用放免法测定血清中肿瘤坏死因子 -α、白介素 - 1β的含量。结果 雷公藤多糖甙能抑制肿瘤坏死因子 -α、白介素 - 1β的水平升高。结论 雷公藤多糖甙对大鼠局灶性脑缺血 /再灌注损伤有保护作用。
Objective To study the role of tumor necrosis factor and interleukin - 1β in cerebral ischemia / reperfusion injury and the effect of Tripterygium Wilfordii glycosides on it. Methods The rat model of cerebral ischemia / reperfusion was established by thread occlusion method. The content of tumor necrosis factor - α, interleukin - 1β in serum was determined by radioimmunoassay. Results Tripterygium glycosides inhibited the increase of tumor necrosis factor-α and interleukin-1β. Conclusion Tripterygium wilfordii polysaccharide has a protective effect on focal cerebral ischemia / reperfusion injury in rats.