为了正确使用汉方药,本次探讨了芍药甘草汤对在药物相互作用方面有重要作用的P-糖蛋白(P-gp)的影响。方法:以维拉帕米为基质,通过ATPase分析法探讨芍药甘草汤对P-gp的抑制活性。以实测值为基础,通过制作的Lineweaver Burk plot及Dixon plot进行芍药甘草汤及甘草的抑制模式的推? In order to correctly use Kampo medicine, the effect of Shaoyao Gancao Decoction on P-glycoprotein (P-gp), which plays an important role in drug interactions, was investigated. Methods: The inhibitory activity of Shaoyao Gancao Decoction on P-gp was investigated by verapamil as a substrate and ATPase assay. Based on the measured values, the inhibition mode of peony root licorice decoction and licorice decoction was developed through Lineweaver Burk plot and Dixon plot.