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血管内皮钙粘着素(vascular endothelial cadherin,VE-cadherin)是血管内皮细胞表面特异的跨膜粘附蛋白。它介导了相邻内皮细胞之间的粘附连接,在保持血管的完整性,调节内皮细胞之间的通透性和细胞内的信号传导中发挥重要作用 ;VE-cadherin对于胚胎发育中血管形成和出生后的血管新生是必需的。VE-cadherin基因的灭活将导致胚胎血管系统无法正确的形成而造成死胎。抗VE-cadherin的抗体能抑制肿瘤组织中血管的新生。VE-cadherin-2是最近发现的一种新的血管内皮钙粘着素。
Vascular endothelial cadherin (VE-cadherin) is a surface-specific transmembrane adhesion protein of vascular endothelial cells. It mediates the adhesion between adjacent endothelial cells and plays an important role in maintaining the integrity of blood vessels, regulating the permeability between endothelial cells and intracellular signaling. VE-cadherin plays an important role in embryonic development of blood vessels Angiogenesis after formation and after birth is required. VE-cadherin gene inactivation will lead to embryonic vasculature can not be formed correctly and cause stillbirth. Anti-VE-cadherin antibodies can inhibit angiogenesis in tumor tissue. VE-cadherin-2 is a newly discovered vascular endothelial cadherin.