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卡马西平(CBZ)和苯妥英钠(DPH)是临床治疗癫痫的主要药物,应用较广泛。由于它们的治疗指数低,安全有效的血药浓度范围窄(CBZ的有效血药浓度范围为4～12μg/ml,DPH的有效血药浓度范围为10～20μg/ml),故对癫痫病人使用CBZ和DPH时进行常规的血药浓度监测,在临床上是十分有益的。作者曾对门诊16例癫痫病例进行CBZ和DPH血药浓度监测,取得一定效果。现报道如下。 一、血药浓度测定方法 仪器 KONTRON 322型HPLC仪,332型可变波
Carbamazepine (CBZ) and phenytoin sodium (DPH) are the main drugs for clinical treatment of epilepsy, and are widely used. Because of their low therapeutic index, safe and effective blood concentration range is narrow (CBZ effective plasma concentration range of 4 ~ 12μg / ml, DPH effective plasma concentration range of 10 ~ 20μg / ml), so the use of epilepsy patients CBZ and DPH routine blood concentration monitoring, in clinical is very useful. The author has 16 outpatients with epilepsy cases CBZ and DPH blood concentration monitoring, and achieved some results. Report as follows now. First, the method of determination of plasma concentration instrument KONTRON 322 HPLC instrument, 332 variable wave