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目的分析正常早孕妇女和稽留流产患者绒毛及蜕膜组织中survivin和Fas蛋白的表达及意义。方法用免疫组化法检测正常早孕妇女和稽留流产患者绒毛和蜕膜组织中survivin和Fas蛋白的表达。结果 Survivin表达早孕组绒毛显著高于稽留流产组绒毛(P<0.05),但早孕组蜕膜与稽留流产组相比无显著性差异(P>0.05),早孕绒毛组织Survivin的最大阳性强度显著高于蜕膜组织(P<0.05)。Fas蛋白表达稽留流产组蜕膜显著高于绒毛及早孕蜕膜(P<0.05)。结论Survivin和Fas蛋白在稽留流产过程中可能发挥重要作用。
Objective To analyze the expression and significance of survivin and Fas in villi and decidua of normal pregnant women and missed abortion patients. Methods Immunohistochemistry was used to detect the expression of survivin and Fas in the chorionic and decidual tissues of normal pregnant women and missed abortion patients. Results There was significant difference in the expression of Survivin between early pregnancy and control group (P <0.05), but there was no significant difference in decidua between the early pregnancy group and the missed abortion group (P> 0.05). The maximum positive intensity of Survivin in early pregnancy was significantly higher In decidual tissue (P <0.05). The expression of Fas protein in missed abortion group was significantly higher than in chorion and early pregnancy decidua (P <0.05). Conclusion Survivin and Fas protein may play an important role in abortion.