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本刊曾报道去B链羧端五肽胰岛素(简称DPI)-K_2HgI_4重原子衍生物的分析,用这个重原子衍生物,运用SIR法得到了一个4(?)分辨率的DPI分子在C_2空间群中排布的初步结果。由于该重原子衍生物质量不够好,所以结果尚待进一步肯定。为了得到DPI分子在晶胞中的确切排布以及原子水平上的三维结构,多对同晶置换法仍是目前测定生物大分子的最有效方法之一,为此,我们在DPI晶体生长及重原子衍生物制备方面做了进一步探索,获得了某些
We have reported to B chain carboxy terminal pentapeptide insulin (DPI) -K_2HgI_4 heavy atom derivatives of the use of this heavy atom derivatives, the use of SIR method has been a 4 (?) Resolution of DPI molecules in C_2 space Preliminary results arranged in the group. The quality of the heavy atom derivatives is not good enough, so the results have yet to be further confirmed. In order to obtain the exact arrangement of DPI molecules in the unit cell and the three-dimensional structure at the atomic level, the multiple isomorphous substitution method is still one of the most effective methods for the determination of biological macromolecules. For this reason, in DPI crystal growth and heavy Further exploration has been made in the preparation of atomic derivatives, obtained some