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目的研究三磷酸腺苷结合转运蛋白G2(ABCG2)和核因子κB(NF-κB)在结直肠癌组织中表达及其临床意义。方法运用免疫组织化学法检测21例结直肠癌组织(A组)及癌旁正常组织(B组)ABCG2和NF-κB蛋白的表达,分析ABCG2与NF-κB表达的相关性及其与临床病理学特征的关系。结果 A组ABCG2阳性表达率为66.7%,与淋巴结转移、临床分期和Dukes分期密切相关(P<0.05),与患者的性别、年龄、病变部位、分化程度、肿瘤大小、浸润深度、脉管神经浸润、远处转移之间无相关性。与B组比较,A组NF-κB高表达,但与临床病理指标之间无明显相关性。A组ABCG2与NF-κB的表达呈正相关(r=0.686,P<0.01)。结论 ABCG2和NF-κB在结直肠癌组织中高表达;ABCG2高表达与临床病理因素密切相关。
Objective To study the expression of adenosine triphosphate transporter G2 (ABCG2) and nuclear factor κB (NF-κB) in colorectal cancer and its clinical significance. Methods The expressions of ABCG2 and NF-κB protein in 21 colorectal cancer tissues (A group) and adjacent normal tissues (B group) were detected by immunohistochemistry. The correlation between ABCG2 and NF-κB expression and clinicopathological factors Neo-Confucianism. Results The positive expression rate of ABCG2 in group A was 66.7%, which was closely related to the lymph node metastasis, clinical stage and Dukes stage (P <0.05), but not with the gender, age, lesion location, degree of differentiation, tumor size, depth of invasion, No correlation between infiltration and distant metastasis. Compared with group B, group A showed high expression of NF-κB, but no significant correlation with clinicopathological parameters. A group of ABCG2 and NF-κB expression was positively correlated (r = 0.686, P <0.01). Conclusion ABCG2 and NF-κB are highly expressed in colorectal cancer tissues. The high expression of ABCG2 is closely related to clinicopathological factors.