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目的探讨ＮＯ供体一硝普钠对促使阴茎勃起的作用。方法选择４２例阳萎患者，采用硝普钠进行阴茎海绵体内注射（ＩＣＩ）；并选择罂粟碱／酚妥拉明进行对照。结果硝普钠ＩＣＩ后：１．阴茎长度、周径等明显改变，增加值与对照相比无显著差异。２．Ｖｉｒａｇ硬度计点表明硝普钠与罂粟碱／酚妥拉明效果之间无明显差异。３．所有测试患者无１例出现低血压或局部不适等副反应，与罂粟碱／酚妥拉明相比各有优劣，但总体差异不大。结论硝普钠作为一种ＮＯ供体可导致阴茎平滑肌松驰，血窦充盈，阴茎勃起，且副反应较小，有临床应用价值。
Objective To investigate the effect of nitric oxide, nitric oxide and sodium nitroprusside on penile erection. Methods Forty-two patients with impotence were enrolled in this study. Intraperoneal injection of sodium nitroprusside (ICI) was performed. Papaverine and phentolamine were selected as controls. Results Sodium nitroprusside after ICI: 1. Penile length, diameter and other significant changes, the added value compared with the control no significant difference. 2. The Virag Durometer point showed no significant difference between the effects of sodium nitroprusside and papaverine / phentolamine. 3. None of the patients tested had side effects such as hypotension or local discomfort, compared with papaverine / phentolamine, but the overall difference was insignificant. Conclusion Sodium nitroprusside, as an NO donor, can lead to relaxation of penile smooth muscle, sinusoidal filling, penile erection with less side effects and clinical value.