论文部分内容阅读
为观察酒精性肝硬化(AC)单核细胞活化与肿瘤坏死因子(TNFα)及可溶性肿瘤坏死因子受体(sTNFRp55、p75)的关系,对32例 AC 血清和外周血单个核细胞上清液进行了检测。一、资料与方法32例经肝穿活检或 CT 及影像学证实为肝硬化,平均年龄51.2岁,均长期饮酒10年以上,排除病毒性肝炎及其他致肝硬附表酒精性肝硬化血清 TNFα及其两类受体的变化化因素而诊断为 AC。收集血清和单个核细胞(12例),后者经酯多糖(LPS)刺激后分离上清液,用 TNFα、sTNFRp55、p75酶标试剂盒(瑞士 F.Hoffmann La Roch AG 公司)检测。二、结果与结论AC 组血清 TNFα、sTNFRp55、p75较正常组明显升高,P值均小于0.01(附表)。AC 组体外单核细胞自发性表达和经 LPS刺激后 TNFα、sTNFRp55、p75的表达均较正常组高(分别为19.77±14.62、263.00±25.05、1933.08±555.44和3372.12±
To observe the relationship between activated monocyte activation of alcoholic liver cirrhosis (AC) and tumor necrosis factor (TNFα) and soluble tumor necrosis factor receptor (sTNFRp55, p75), 32 cases of AC serum and peripheral blood mononuclear cell supernatant The test. Materials and Methods 32 cases of liver biopsy or CT and imaging confirmed liver cirrhosis with an average age of 51.2 years old, were long-term drinking more than 10 years, excluding viral hepatitis and other liver cirrhosis caused by alcoholic cirrhosis serum TNFα And its two types of receptor changes in the diagnosis of AC. Serum and mononuclear cells (12) were collected, which were stimulated with lipopolysaccharide (LPS) and the supernatants were separated and detected by TNFα, sTNFRp55, p75 enzyme labeling kit (F. Hoffmann La Roch AG, Switzerland). Second, the results and conclusion Serum TNFα, sTNFRp55, p75 in AC group were significantly higher than the normal group, P values ?? were less than 0.01 (Schedule). The expression of TNFα, sTNFRp55 and p75 were significantly higher in AC group than those in normal group (19.77 ± 14.62, 263.00 ± 25.05, 1933.08 ± 555.44 and 3372.12 ±