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The title compound N-((1-cyclohexyl-1H-tetrazol-5-yl)(5-methyl-1,2,3-thiadiazol-4-yl) methyl)-4-nitrobenzenamine (C17H20N8O2S, Mr = 400.47) was synthesized via Ugi fourcomponents condensation reaction (U-4CR), and its structure was characterized by IR, 1H NMR, high-resolution mass spectrometry and single-crystal X-ray diffraction. The crystal belongs to orthorhombic, space group Pna21 with a = 20.390(2), b = 12.9660(14), c = 6.9399(8) , β = 90.00°, Z = 4, V = 1834.7(3)3, Mr = 400.47, Dc = 1.450 g/cm3, μ = 0.210 mm-1, F(000) = 840, R = 0.0348 and wR = 0.0717. X-ray analysis reveals that the dihedral angles formed between the thiadiazole and tetrazole rings, the benzene and tetrazole rings and the thiadiazole and benzene rings are 62.59, 86.73 and 70.07°, respectively. Three intermolecular hydrogen bonds N(1)-H(2)···N(6), C(4)-H(4B)···O(2) and C(17)-H(17)···N(3) are observed. Bioassay shows that the title compound has antifungal and antivirus activities against tobacco mosaic virus.
The title compound N - (1-cyclohexyl-1H-tetrazol-5-yl) methyl-4-nitrobenzenamine (C17H20N8O2S, Mr = 400.47) was synthesized via Ugi 4components condensation reaction (U-4CR), and its structure was characterized by IR, 1H NMR, high-resolution mass spectrometry and single-crystal X- ray diffraction. The crystal belongs to orthorhombic, space group Pna21 with a = 20.390 B = 12.9660 (14), c = 6.9399 (8) β, β = 90.00 °, Z = 4, V = 1834.7 33, Mr = 400.47, Dc = 1.450 g / cm3, μ = 0.210 mm-1, F (000) = 840, R = 0.0348 and wR = 0.0717. X-ray analysis reveals that the dihedral angles formed between the thiadiazole and tetrazole rings, the benzene and tetrazole rings and the thiadiazole and benzene rings are 62.59 , 86.73 and 70.07 °, respectively. Three intermolecular hydrogen bonds N (1) -H (2) N (6), C (4) -H (4B) Bioassay shows that the title compound has antifungal and antivirus activities against tobacco mosaic virus.