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国内外对肿瘤间质反应和预后关系的报告屡见不鲜。Bery首先提出乳腺癌间质具有明显浆细胞浸润者,术后5年生存率较高。Hawley等指出,胃癌等也有与乳腺癌同样的间质反应。Underwood等认为,因局部免疫球蛋白增高,间质炎细胞反应是宿主免疫性反应。淋巴、浆细胞反应明显时,称具有淋巴组织间质的胃癌,为特殊类型,其预后较好。Black等将胃癌周围淋巴细胞浸润的程度分为0～4级,4级者均存活5年以上。Watanabe等也报告胃癌间质有大量淋巴、浆细胞弥
Reports on the relationship between tumor interstitial response and prognosis have been reported at home and abroad. Bery first proposed that there was a significant plasma cell infiltration in the stroma of the breast cancer, with a 5-year survival rate. Hawley et al. pointed out that gastric cancer also has the same interstitial reactions as breast cancer. Underwood et al. believe that, due to the increased local immunoglobulin, the interstitial cell reaction is the host immune response. When the lymphocyte and plasma cell reaction are obvious, gastric cancer with lymphoid stroma is a special type, and its prognosis is good. Black et al. classified the degree of lymphocyte infiltration around the stomach cancer into 0 to 4 grades, and all of the 4 grades survived for more than 5 years. Watanabe et al. also reported a large number of lymphoid and plasma cells in gastric cancer.