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柳氮磺胺吡啶（SASP）具抗生育作用。本文将合成SASP的原料磺胺吡啶及吡啶置培养的成年雄性SD大鼠的附睾各段上皮细胞中，共同孵育11天后，作培养细胞的形态学观察及上清液的生化测定。结果表明用药组与对照组的细胞在光镜下未见明显差异；磺胺吡啶组上清液内的唾液酸含量显著增高，在附睾尾部尤为明显（P＜0．01）；用药组与对照组的α－1，4糖苷酶的活性无显著差异。实验结果提示：磺胺吡啶对大鼠附睾上皮细胞的功能可有一定的影响。
Sulfasalazine (SASP) has anti-fertility effects. In the present study, the epithelial cells of epididymal sections of adult male SD rats, which were synthesized by SASP and sulfapyridine and pyridine respectively, were cultured together for 11 days. The morphological observation of the cultured cells and the biochemical determination of the supernatant were performed. The results showed that there was no significant difference in the cells of the drug-treated group and the control group under the light microscope; the sialic acid content of the sulfapyridine group supernatant was significantly increased, especially in the tail of the epididymis (P <0.01) Alpha-1, 4 glucosidase activity was not significantly different. The experimental results suggest that sulfadiazine may have some effect on the function of epididymal epithelial cells in rats.