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目的观察香荚兰乙酮对醋酸脱氧皮质酮(DOCA)盐高血压大鼠血压及大动脉结构的影响。方法 34只SD大鼠分为假手术组(n=10),DOCA盐高血压模型组(模型组,n=13)和香荚兰乙酮治疗组(治疗组,n=11),模型组和治疗组大鼠于左肾切除术1 wk后开始给药(DOCA 12.5 mg.wk-1皮下注射,1%NaCl饮水;治疗组饮水中加入1.5 mmol.L-1香荚兰乙酮),共5 wk。所有动物在术后wk 2,4,6测定尾动脉血压;6 wk后通过超声活体观察颈总动脉内膜-中膜厚度(IMT),并取胸主动脉测定血管中层厚度。结果模型组大鼠血压呈逐步升高趋势,wk 6治疗组大鼠血压明显下降[(140.6±10.5)mmHg vs.(166.6±13.5)mmHg,P<0.01],胸主动脉中层厚度[(165.52±33.65)μm vs.(194.25±17.91)μm,P<0.05]及颈动脉IMT[(53.33±10.22)μm vs.(78.00±12.96)μm,P<0.05]均显著降低。结论香荚兰乙酮干预可明显降低DOCA盐高血压大鼠尾动脉血压,抑制颈动脉内IMT的增厚,降低胸主动脉中层厚度。
Objective To observe the effects of Vanilla flavone on blood pressure and arterial structure in DOCA hypertensive rats. Methods Thirty-four SD rats were randomly divided into sham operation group (n = 10), DOCA saline hypertensive group (model group, n = 13) and vanilla acetate treatment group The rats in the treatment group were given a dose of 12.5 mg.wk-1 after subcutaneous nephrectomy and 1% NaCl drinking water for 1 wk after the left nephrectomy. The rats in the treatment group were given 1.5 mmol.L-1 vanadyl ketone 5 wk. The caudal artery blood pressure was measured in all animals after wk 2, 4, 6 and 6 weeks. The intima - media thickness (IMT) of common carotid arteries was observed by ultrasonic living after 6 weeks and the thickness of blood vessel was measured by thoracic aorta. Results The blood pressure of rats in model group was gradually increased. The blood pressure in wk 6 group was significantly lower than that in wk 6 group [(140.6 ± 10.5) mmHg vs (166.6 ± 13.5) mmHg, P <0.01] ± 33.65 μm vs 194.25 ± 17.91 μm, P <0.05] and carotid IMT [(53.33 ± 10.22) μm vs. (78.00 ± 12.96) μm, P <0.05]. Conclusion The intervention of vanadyl ethyl ketone can significantly reduce the blood pressure of tail artery in DOCA hypertensive rats, inhibit the thickening of IMT in the carotid artery and decrease the thickness of thoracic aorta.