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目的：研究关附乙酯（ＤＧＦＡ）对大鼠离体心房肌的作用。方法：常规离体器官实验法。结果：ＤＧＦＡ降低了大鼠离体右心房肌的收缩力（Ｐ＜０．０５）并呈浓度依赖性，对右心房的自律性无明显影响；４μｍｏｌ·Ｌ－１ＤＧＦＡ能显著抑制肾上腺素诱发的大鼠离体左房肌的自律性，药前肾上腺素（ＡＤ）的浓度为７．９２±２．７５μｍｏｌ·Ｌ－１，药后１０ｍｉｎ，ＡＤ的浓度升至１６．７７±６．１２μｍｏｌ·Ｌ－１（ｎ＝６，Ｐ＜０．０１）；４μｍｏｌ·Ｌ－１ＤＧＦＡ在药后１０ｍｉｎ，使大鼠离体左房的功能性不应期（ＦＲＰ），由药前的１３０±１２．６ｍｓ延长至１５０±１２．６ｍｓ（ｎ＝６，Ｐ＜０．０５），但对离体大鼠左房肌的兴奋性无明显影响。结论：ＤＧＦＡ的抗心律失常作用可能与其抑制Ｎａ＋、Ｃａ２＋跨膜转运有关。
OBJECTIVE: To study the effects of guanylacetate (DGFA) on rat isolated atrial muscle. Methods: Conventional isolated organ experiments. RESULTS: DGFA reduced the contractility of isolated right atrial muscle in rats (P < 0.05) in a concentration-dependent manner, and had no significant effect on the autoregulation of the right atrium; 4 μmol·L-1DGFA could significantly inhibit the epinephrine-evoked The self-discipline of isolated left atrial muscle in rats, the concentration of preadjuvant adrenaline (AD) was 7.92±2.75 μmol·L-1, and after 10 min, the concentration of AD increased to 16.77±6.12 μmol. L-1 (n=6, P<0.01); 4μmol·L-1DGFA, 10 min after drug administration, left the functional left refractory period (FRP) of rats left atrial, 130±12 before drug. 6ms prolonged to 150±12.6ms (n=6, P<0.05), but there was no significant effect on the excitability of left atrial muscle in isolated rats. Conclusion: The antiarrhythmic effect of DGFA may be related to its inhibition of Na+ and Ca2+ transmembrane transport.