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Measure index system of technical innovation in medium and small manufacturing enterprises is established according to principles of exploration, adaptability, standardization, generalization, feasibility, comparability and combination of economic benefit and continual development.It includes index of technical innovation capacity, informational administration on technical innovation, and investment of technical innovation, economic benefit, green technical level, social contribution and other influential indexes.Approach to measure of technical innovation in medium and small manufacturing enterprises is presented based on combination of grey relation and fuzzy hiberarchy analysis, and conclusions are drawn based on practical analysis of 20 medium and small enterprises, which provides the basis for the medium and small enterprises to select technical innovation policies and the government to constitute relative policies.