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核因子κB(nuclear factor kappa B,NF-κB)是体内重要的转录因子,是一类能与多种基因启动子或增强子部位κB序列(GGGACTTTCC)发生特异性结合并促进其转录的蛋白质。1986年Sen等[1]首次从B淋巴细胞核抽提物中,检测到一种能与免疫球蛋白κ轻链基因增强子κB序列特异结合的蛋白质
Nuclear factor kappa B (NF-κB) is an important transcription factor in vivo. It is a kind of protein that can specifically bind with GGGACTTTCC and promote the transcription of many kinds of gene promoter or enhancer. In 1986, Sen et al [1] for the first time from the B lymphocyte nuclear extracts detected a protein that binds specifically to the immunoglobulin κ light chain enhancer κB sequence