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目的:通过实验研究验证地黄健忆丸的药效,为其临床应用提供依据。方法:通过该药对模型动物空间记忆能力、被动回避条件反射记忆的影响观察其改善痴呆后记忆作用,通过对模型动物脑组织SOD、MDA的影响观察其改善痴呆脑损伤的药效。结果:地黄健忆丸具有缩短水迷宫潜伏期、延长避暗箱潜伏期及减少错误次数的作用;给予该药后模型动物脑组织SOD活力增高、MDA含量降低。结论:地黄健忆丸具有改善痴呆模型脑组织损伤改善其记忆功能的疗效。
Objective: To verify the efficacy of Dihuang Jian Yi Wan through experimental research, and provide evidence for its clinical application. Methods: The drug was used to improve the memory effect of dementia by observing the spatial memory ability of the model animals and passive avoidance conditioned reflex. The effect of improving the dementia brain injury was observed by observing the effect of SOD and MDA on the brain tissue of model animals. Results: Dihuang Jian Yi Pill has the effect of shortening the latency of water maze, prolonging the incubation period and reducing the number of mistakes. After the medicine was given, the activity of SOD and the content of MDA in the brain tissue increased. Conclusion: Dihuang Jian Yi Wan can improve the memory function of brain tissue of dementia model.