A new ceramide, humesamide, was isolated from the soft coral Cladiella humest Verseveldt, which was collected from Linshui County of Hainan Province. Its structure was established by spectroscopic analysis and chemical degradation methods. A new ceramide, humesamide, was isolated from the soft coral Cladiella humest Verseveldt, which was collected from Linshui County of Hainan Province. Its structure was established by spectroscopic analysis and chemical degradation methods.