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目的:分析2007年宁波市255例左氧氟沙星不良反应发生的基本情况,为临床药品不良反应监测及合理用药提供参考方法:以Excel电子表格形式下载2007年药品不良反应报告表,对有关数据进行适当转换后,进行统计、分析。结果:255份左氧氟沙星不良反应报告中,累及的系统器官主要为皮肤及其附件(42.55%)、胃肠道系统(11.35%)、神经系统(10.64%)、全身性损害(7.09%)。244例(95.69%)药品不良反应由静脉给药途径所致。新的、严重的不良反应较少(7.05%)。结论:左氧氟沙星不良反应高发生率与临床应用广泛有关,使用管理也亟待加强,包括商品名管理、医生处方规范,特别对老年人要慎重使用,18岁以下未成年人应避免使用,以减少不良反应发生。
OBJECTIVE: To analyze the basic situation of 255 cases of levofloxacin adverse reactions in Ningbo City in 2007, and to provide a reference method for the monitoring of adverse reactions of clinical drugs and rational drug use: download the 2007 Adverse Drug Reaction Report form in the form of Excel spreadsheet, and properly convert the data After statistics, analysis. Results: 255 levofloxacin adverse reactions reported mainly involving the skin and its appendages (42.55%), the gastrointestinal system (11.35%), the nervous system (10.64%), and systemic injuries (7.09%). 244 cases (95.69%) adverse drug reactions caused by intravenous route. New, serious adverse reactions less (7.05%). Conclusion: The high incidence of adverse reactions of levofloxacin is related to the wide range of clinical applications. Management of the use of the drugs is also urgently needed to be strengthened, including the management of trade names and prescriptions by doctors. Care should be taken especially for the elderly, and minors under 18 years of age should be avoided to reduce the adverse effects The reaction took place.