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目的观察注射用尤瑞克林对急性期脑梗死患者红细胞压积(HCT)及凝血指标水平的影响。方法对2015年6月~2016年3月于本院就诊的55例急性脑梗死患者的临床资料进行回顾性队列分析,根据是否在常规治疗的基础上加用尤瑞克林分为治疗组(25例)和对照组(30例),观察治疗前后患者红细胞压积及凝血指标水平的变化。结果治疗组治疗后与治疗前比较,HCT明显下降(T=4.543,P<0.01),凝血酶原时间(PT)、凝血活酶时间(APTT)、凝血酶时间(TT)延长(P<0.05),纤维蛋白原(FIB)显著降低(T=3.988,P<0.01),并且治疗组与对照组治疗后比较有明显差异(P<0.01)。结论对于急性脑梗死患者早期应用尤瑞克林治疗可明显降低HCT和FIB水平,这不仅能降低患者血液黏度,改善异常的血流动力学,而且间接反映了该药具有增加脑血流灌注和促进侧支循环开放的作用。
Objective To observe the effect of uracil injection on hematocrit (HCT) and coagulation index in patients with acute cerebral infarction. Methods A retrospective cohort analysis was performed on the clinical data of 55 patients with acute cerebral infarction who were treated in our hospital from June 2015 to March 2016. The patients were divided into treatment group (n = 25 cases) and control group (30 cases). The changes of hematocrit and coagulation index before and after treatment were observed. Results After treatment, the HCT decreased significantly (P <0.05) in the treatment group compared with that before treatment (T = 4.543, P <0.01), prolonged prothrombin time (PT), thromboplastin time (APTT) and thrombin time ), Fibrinogen (FIB) decreased significantly (T = 3.988, P <0.01), and there was a significant difference between the treatment group and the control group after treatment (P <0.01). Conclusions The early application of ureclin in acute cerebral infarction patients can significantly reduce the level of HCT and FIB, which not only can reduce the patient’s blood viscosity, improve the abnormal hemodynamics, but also indirectly reflects the drug has increased cerebral blood flow and Promote the opening up of collateral circulation.