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布比卡因(Bupivacaine Hcl,勃比伏卡因,丁哌卡因)系—酰胺型长效局部麻醉药,由Ekenstam于1957年首先合成,1963年开始应用于临床,我国80年代初才于临床试用。其作用机制与其它酰胺型局麻药(如利多卡因、卡波卡因)相似,即药物与血浆蛋白结合后,经各个器官到达肝脏代谢。它有很多优点:①麻醉力较强(约为卡波卡因的3倍)。②持续时间较长,可达7～8小时以上(约为利多卡因的2倍多)。③对呼吸系统和循环系统影响较小。④本品较难扩散到胎儿中去,母体与胎儿药物的比例仅为4:1(利多卡因为2:1,普鲁卡因50%)。⑤价格较利多卡因便宜。由于上述优点,它深受患者及医生的
Bupivacaine (Bupivacaine Hcl, Bobepivacaine, Bupivacaine) - amide long-acting local anesthetic, first synthesized by Ekenstam in 1957, 1963 began to be used in clinical, our country only in early 1980s Clinical trial. Its mechanism of action and other amide-type local anesthetics (such as lidocaine, carbocaine) is similar to the drug and plasma protein binding, through various organs to reach the liver metabolism. It has many advantages: ① narcotic strong (about 3 times as much as carbofuran). ② longer duration, up to 7 to 8 hours or more (about twice as much lidocaine). ③ less impact on the respiratory system and circulatory system. ④ This product is more difficult to spread to the fetus, maternal and fetal drug ratio of only 4: 1 (lidocaine 2: 1, procaine 50%). ⑤ price cheaper than lidocaine. Because of the above advantages, it is well received by patients and doctors