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目的:探讨方谷氨酰胺和氟西汀联合治疗肠易激综合征的临床效果。方法:选择我院2008年6月～2011年6月肠易激综合征患者86例,上述患者分为观察组和对照组。观察组患者给予复方谷酰胺,每次4粒,每天3次,同时给予氟西汀胶囊,每次5mg,每天2次,连续治疗8周。对照组单独应用复方谷氨酰胺,用法和用量痛观察组。2组患者治疗过中观察临床症状改善情况。结果:观察组治疗后完全缓解37例,部分缓解4例,无效2例,总缓解率为95.3%。对照组治疗后完全缓解28例,部分缓解5例,无效10例,总缓解率76.7为。观察组总缓解率显著高于对照组,差异有统计学意义好(P<0.05)。结论:复方谷氨酰胺和氟西汀联合应用治疗肠易激综合征疗效显著,值得借鉴。
Objective: To investigate the clinical effect of combination of glutamine and fluoxetine in the treatment of irritable bowel syndrome. Methods: 86 cases of irritable bowel syndrome were selected from June 2008 to June 2011 in our hospital. The above patients were divided into observation group and control group. The patients in the observation group were given compound glutamine 4 times a day for 3 times. Fluoxetine capsules were also given for 5 mg twice daily for 8 weeks. Control group alone compound glutamine, usage and dosage of pain observation group. Two groups of patients treated to observe the improvement of clinical symptoms. Results: The observation group was completely relieved after treatment in 37 cases, partial remission in 4 cases, 2 cases were ineffective, the overall response rate was 95.3%. Control group after treatment, complete remission in 28 cases, partial remission in 5 cases, ineffective in 10 cases, the overall response rate was 76.7. The total remission rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P <0.05). Conclusion: The combined treatment of compound glutamine and fluoxetine has significant therapeutic effect on irritable bowel syndrome and is worth learning from.