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用离体兔胸主动脉条研究东莨菪碱(scopolamine,Scop)扩张血管作用的可能机理。Scop与维拉帕米对CaCl2和Scop对KCI所致兔胸主动脉条收缩的量-效曲线右移,最大反应降低,呈现非竞争性拮抗,其pD'2分别为3.4,5.8和3.4。两药能明显抑制NE的依赖内Ca(2+)性收缩,Scop对NE的依赖外Ca(2+)性收缩几无影响,表明Scop可能主要作用于电压依赖性的钙通道,阻断Ca(2+)内流。
In vitro rabbit thoracic aortic strips were used to investigate the possible mechanism of scopolamine (Scop) dilation of blood vessels. Scop and verapamil had a dose-response curve of CaCl2 and Scop to KCI-induced contractions of thoracic aorta to the right, with the maximal response decreasing and showing noncompetitive antagonism with pD’2 of 3.4 and 5, respectively. 8 and 3.4. Both drugs could significantly inhibit NE-dependent intracellular Ca (2+) contractions, and Scop had no effect on NE-dependent extracellular Ca (2+) contractions, indicating that Scop may mainly act on voltage-dependent calcium channels and block Ca 2+ ) Influx.