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目的:观察雌二醇对大鼠心脏间歇性低氧抗心律失常及抗氧化作用的影响。方法:结扎和放松冠脉造成心脏缺血及再灌注,以诱发心律失常;并测定心室肌超氧化物岐化酶(SOD)活性和丙二醛(MDA)含量。结果:与对照组相比较,间歇性低氧28天组和间歇性低氧14天加雌二醇组在缺血期和再灌注期,心律失常评分(AS)都显著降低。单纯雌二醇处理组的缺血期AS明显降低,而再灌注期AS无变化。间歇性低氧14天组、溶剂组的AS无显著变化。间歇性低氧28天组和间歇性低氧14天加雌二醇组的SOD活性明显升高,MDA含量明显下降。在间歇性低氧14天组、溶剂组和单纯雌二醇处理组,SOD活性和MDA含量与对照组相比较无明显差异。结论:雌二醇可加强间歇性低氧大鼠抗缺血、再灌注心律失常及心肌的抗氧化作用。
Objective: To observe the effect of estradiol on intermittent hypoxia-induced arrhythmia and anti-oxidation in rat heart. Methods: Cardiac ischemia and reperfusion were induced by ligation and relaxation of the coronary arteries to induce arrhythmia. The activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) were measured. Results: Compared with the control group, the intermittent hypoxia 28 days group and the intermittent hypoxia 14 days plus estradiol group significantly decreased the arrhythmia score (AS) during ischemia and reperfusion. Ischemia was significantly reduced in the estradiol-treated group, while AS was unchanged in the reperfusion period. Intermittent hypoxia 14 days group, solvent group AS no significant change. Intermittent hypoxia 28 days group and intermittent hypoxia 14 days plus estradiol group SOD activity was significantly increased, MDA content decreased significantly. There was no significant difference in SOD activity and MDA content between the 14-day intermittent hypoxia group, the solvent group and the estradiol-only group compared with the control group. Conclusion: Estradiol can enhance anti-ischemia, reperfusion arrhythmia and myocardial anti-oxidation in rats with intermittent hypoxia.