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GnRH是在生殖系统中起重要作用的十肽片段,已报道GnRH在不同生殖器官中的表达,并且一些研究显示GnRH在胚胎发育、种植和稳定妊娠方面起作用。最近,一个基因编码的GnRH的第二种形式(GnRH-Ⅱ)从人脑中分离出来,该GnRH-Ⅱ的十肽排列顺序与鸡的GnRH-Ⅱ(cGnRH-Ⅱ)完全相同,在哺乳动物cGnRH-Ⅱ是GnRH类中较常见的一种,但在人体中表达的组织特异性和生理机能尚未被描述,为揭
GnRH, a decapeptide fragment that plays an important role in the reproductive system, has reported the expression of GnRH in different genital organs and some studies have shown that GnRH plays a role in embryonic development, implantation and stable pregnancy. Recently, the second form of a gene encoding GnRH (GnRH-II) was isolated from the human brain and the decapeptide sequence of GnRH-II was exactly the same as that of chicken GnRH-II (cGnRH-II) cGnRH-II is the more common type of GnRH, but the tissue-specific and physiological functions expressed in humans have not been described yet