60年代即已发现,老年痴呆患者脑内许多区域,特别是大脑皮层和海马区,有许多异常的纤维蛋白沉积。并且发现,沉积物的量与病人生前病情的严重程度密切相关。这些纤维蛋白沉积物的形成,可能与交联键的随龄增多有关。Bailey等认为,在衰老过程中,胶原中不溶解的稳定的交联键不断增多,很可能是由不稳定的交联键转化而来。 In the 1960s, it was discovered that many areas of brain in Alzheimer’s patients had abnormal fibrin deposition in many areas, especially in the cerebral cortex and hippocampus. It was also found that the amount of sediment is closely related to the severity of the patient’s condition before his death. The formation of these fibrin deposits may be related to the increasing age of cross-linking bonds. Bailey et al. believe that during the aging process, the insoluble, stable, cross-linking bonds in collagen increase continuously, which is likely to be due to unstable cross-linking.