瘦素为脂肪细胞分泌的保持机体能量平衡的激素。瘦素受体的分布广泛 ,瘦素通过中枢神经系统调节能量代谢 ,也有广泛的周围作用 ,通过胰腺、肝脏、骨骼肌等发挥其作用。瘦素对葡萄糖的产生、转运、代谢及脂肪的分解合成有影响 ,并且作用于其它影响能量代谢的因子 ,直接或间接地影响能量平衡。瘦素和受体的作用障碍 ,可导致肥胖、胰岛素抵抗等能量代谢异常 Leptin is a hormone secreted by adipocytes that maintains the body’s energy balance. Leptin receptors are widely distributed. Leptin regulates energy metabolism through the central nervous system. It also has extensive peripheral effects and exerts its effects through the pancreas, liver and skeletal muscle. Leptin affects glucose production, transport, metabolism, and fat breakdown and synthesis, and acts on other factors that affect energy metabolism, directly or indirectly affecting the energy balance. Leptin and receptor dysfunction, can lead to obesity, insulin resistance and other energy metabolism