海蓝组织细胞增生症(Sea-blue histiocytosis SBH)为一特殊类型的全身组织细胞增生性疾病,比较少见。近期我院确珍一例,并进行了家系调查,发现姐妹三人同患SBH增生症,现报告如下。病例报告先证者女性,30岁。因脾大原因待查于1990年3月8日入院。患者自幼体弱,极易“感冒”。13岁时因发热住院发现肝脾轻度肿大,此后逐渐增大,因无腹部不适未予重视。近三年来反复腹泻及皮肤出现乌青块,常感头昏、乏力但能坚持工作。近三月上述症 Sea-blue histiocytosis (SBH) is a special type of systemic histiocytosis, which is rare. Recently, our hospital is indeed a case of Jane, and a pedigree survey found that three sisters with SBH hyperplasia, are as follows. Case report proband Female, 30 years old. Due to splenomegal cause to be investigated on March 8, 1990 admitted. Patients from infirmity, easily “cold.” 13-year-old hospitalized for fever found liver and spleen mild enlargement, then gradually increased, because no abdominal discomfort was not taken seriously. Repeated diarrhea in the past three years and the skin appears black block, often feel dizzy, weak but can keep working. Nearly three months the above symptoms